ea0011p461 | Endocrine tumours and neoplasia | ECE2006
Tagliati F
, Zatelli MC
, Bottoni A
, Piccin D
, Luchin A
, Culler MD
, degli Uberti EC
Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTR) by several pathways in many tissues. We previously demonstrated that SRIH, by activating SHP-1, inhibits cell proliferation of the human Medullary Thyroid Carcinoma (MTC) cell line, TT, which expresses all SSTR. However, the effects of SRIH on cell cycle proteins have not been investigated, so far. We therefore investigated the effects of SRIH and of a selective SSTR...